Abstract
For up to 6 days after administration of tritiated methadone the eyes of albino (Sprague Dawley) and pigmented (Long Evans) rats and frogs (Rana pipens) were assayed for methadone and metabolites in various eye substructures. The pigmented structures of the eye were found to contain the highest concentration of radioactivity at all time periods tested. At 6 days after administration of a single dose the pigmented epithelium of the rat retina showed a 100 times greater concentration of radioactivity than the blood. At 6 hours after dosage the pigmented eyes showed a 40 times greater concentration than the albino eyes suggesting that methadone does have a strong affinity for the pigmented structures of the eye.
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