Methacrylic Acid Co-Polymers: Crucial agents for the Colon Targeted Oral Drug Delivery System

Abstract

The objective of this research was to formulate an Ornidazole tablet capable of delivering the drug intact to the colon for the treatment of IBD, ulcerative colitis, and Crohn's disease. In the current investigation, pH-independent and pH-dependent polymers were used to target the Ornidazole tablet to the colon. This study evaluated two time-dependent (sustained release) polymers (Eudragit RS and Eudragit RL) and one pH-dependent polymer (Eudragit S100). The influence of the two formulation variables of the colon drug delivery system on the two response variables were examined simultaneously using a statistical 32-Full factorial design. X1 Ratio of Eudragit RS 100 to Eudragit RL 100 and X2 % weight gain with Eudragit S 100 were treated as independent variables in a factorial design, while Y5 and Y12 were treated as dependent variables. Through this procedure, a total of nine F9 samples were produced. Y5 in-vitro release should not exceed 10%, whereas Y12 should surpass 85%. Based on these results, batch B8 is considered the finest of all cohorts. According to the results, the enhanced formulation provides optimal intact drug delivery to the targeted region.