Abstract
Metformin, Oxidative Stress, and Infertility: A Way Forward.
Highlights
Infertility is a significant public health problem and its diagnosis and treatment are stressful, invasive and costly
Exposures associated with Oxidative stress (OS) and pregnancy outcomes have so far been studied in relation to Poly Cystic Ovarian Syndrome (PCOS) only
Metformin induces increase in NAD/NADH ratio by inducing increased expression of NAMPT mRNA and protein expression, resulting in enhanced SIRT1 expression and activity in a dose-dependent fashion (Caton et al, 2010)
Summary
Infertility is a significant public health problem and its diagnosis and treatment are stressful, invasive and costly. Cellular redox activity is a normal mechanism of the male and female reproductive system but its inequilibrium affects the fertility by hindering attainment and maintenance of oocyte developmental potential during in vivo processes including ovarian aging. An independent study conducted in Pakistan suggests that functions of SIRT1 are affected by various post-transcriptional activities; increased by phosphorylation, while glycosylation decreased it (Hanover et al, 2010).
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