Abstract
Most cancers have intact mitochondria function and we previously showed that mitochondria metabolism and ROS is essential for tumorigenesis. However, there are a subset of cancers which arise from mutations which abolish activity of TCA cycle enzymes, including Fumarate Hydratase (FH) deficient renal cancer cells. While oxygen consumption is severely reduced in FH deficient human cancer cells, we uncovered that they are still dependent on mitochondrial metabolism and ROS for cell proliferation. Based on these results we propose that mitochondrial metabolism and/or ROS could be an attractive target for therapy. We will discuss the role of mitochondria in regulating cancer and how metformin might exert its anti-tumorigenic properties by inhibiting certain aspects of mitochondrial function.
Highlights
Most cancers have intact mitochondria function and we previously showed that mitochondria metabolism and ROS is essential for tumorigenesis
There are a subset of cancers which arise from mutations which abolish activity of TCA cycle enzymes, including Fumarate Hydratase (FH) deficient renal cancer cells
While oxygen consumption is severely reduced in FH deficient human cancer cells, we uncovered that they are still dependent on mitochondrial metabolism and ROS for cell proliferation
Summary
Most cancers have intact mitochondria function and we previously showed that mitochondria metabolism and ROS is essential for tumorigenesis. Navdeep S Chandel From Metabolism, Diet and Disease 2014: Cancer and metabolism Washington DC, USA.
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
