Metformin Impairs the Cardiorespiratory Fitness Adaptation to High-Intensity Power Training in Older Adults With Type 2 Diabetes: Results From the GREAT2DO Randomised Controlled Trial

M Hollings,N De Vos,D Simar,R Zhao,A O'Sullivan,M Fiatarone Singh,Y Mavros,S Blair,M Climstein,J Meiklejohn,Y Wang,S Kay,M Baker,N Singh,B Baune,K Anderberg

doi:10.1016/j.hlc.2022.06.010

Metformin Impairs the Cardiorespiratory Fitness Adaptation to High-Intensity Power Training in Older Adults With Type 2 Diabetes: Results From the GREAT2DO Randomised Controlled Trial

M Hollings, N De Vos + Show 14 more

https://doi.org/10.1016/j.hlc.2022.06.010

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Journal: Heart Lung and Circulation

Publication Date: Jan 1, 2022

Affiliation: University of Sydney, UNSW Sydney, Longyan University, Hebrew SeniorLife, University of South Carolina, Southern Cross University, Baker IDI Heart and Diabetes Institute, Australian Catholic University, University of Adelaide, University of Münster

#High Velocity Resistance Training #Cardiovascular Mortality In Type + Show 8 more

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Abstract

Cardiorespiratory fitness (CRF) is a strong, modifiable predictor of cardiovascular mortality in type 2 diabetes (T2D). Metformin is commonly prescribed for T2D management and is known to impair CRF adaptations to aerobic training, however its effect on CRF adaptations to high-intensity, high velocity resistance training (Power training; POWER) has never been studied.

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