Abstract
Article AbstractBecause this piece does not have an abstract, we have provided for your benefit the first 3 sentences of the full text.Two-thirds of patients in long-term treatment with a second-generation antipsychotic (SGA) experience weight gain. Weight gain might be due to receptor blockade to H1 receptors (as with tricyclic antidepressants) and to 5-HT2C receptors, impaired metabolic regulation, down-regulation of appetite suppression, and less physical activity due to sedation. Metformin promotes the decrease of glucose absorption, suppression of gluconeogenesis in liver, stimulation of glucose uptake in skeletal muscle, and augmentation of insulin activity.
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