Abstract
Insulin is one of drug of choice in lowering blood glucose in diabetes patients with or without infection. Interleukin (IL)-10 an anti-inflammatory cytokine, plays a protective role in diabetes. The lack of IL-10 associated to development and progression of insulin resistance. On the other hands, Interferon (IFN)-γ elevation is one of the indicators of successful treatment in active TB infection and IL-10 inhibits IFN-γ secretion. Metformin has ability in increasing insulin response and also has protective effect against TB in DM patients. However the relationship between metformin and insulin induced IL-10 and metformin enhanced anti tuberculosis remains unclear.
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