Abstract
In 22 patients aged 24-65 without diabetes mellitus (8 with primary hypothyroidism, 9 with nontoxic nodular goiter and 5 with differentiated thyroid carcinoma not less than 6 mo after surgery) the study was conducted with the aim to discover whether metformin (1 g/day) added to the fixed dose of L-thyroxine (in average 66.4 mcg/day) demonstrates any additional inhibitory effect on blood serum TSH level. In 11 responding to such treatment patients (practically, not depending of the type of thyroid pathology) this additional effect was rather significant (-72.8%, р = 0.035) and was not associated with change in the fT4 level. Supporting and expanding observations of R. Vigersky et al. (2006), this approach warrants further study especially in relation to discovery of the factors predicting mentioned favourable metformin effect.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.