Metatropic Dysplasia - Description of a Newborn with Suspected Epiphyseal Dysplasia

Byrwa Agnieszka,Adamiecka Paulina,Jakubowska-Pietkiewicz Elżbieta,Michałus Izabela

doi:10.23937/2572-3243.1510070

Abstract

Metatropic Dysplasia - Description of a Newborn with Suspected Epiphyseal Dysplasia

Highlights

Fibromyalgia syndrome (FMS) is a chronic, non-articular, rheumatologic disorder specified with chronic systemic musculoskeletal pains with unknown etiology, morning stiffness, fatigue, sleep disorder, multiple tender points, low pain threshold, symptoms of depression and anxiety, and intestinal dysmotility [1].The pathogenesis of FMS is still unknown
Regression analyses demonstrated that FMS patients with older age (45 and above), and higher body mass index (BMI) (30 and above) had a higher probability of having severe Vitamin D deficiency (VDD)
To evaluate if there were specific demographics associated with severe VDD, we examined the correlations between vitamin D levels with age or BMI

Summary

Introduction

Fibromyalgia syndrome (FMS) is a chronic, non-articular, rheumatologic disorder specified with chronic systemic musculoskeletal pains with unknown etiology, morning stiffness, fatigue, sleep disorder, multiple tender points, low pain threshold, symptoms of depression and anxiety, and intestinal dysmotility [1]. The pathogenesis of FMS is still unknown. It appears to be related to a neurotransmitter imbalance and upregulation of inflammatory pathways in the central nervous system (CNS), resulting in central amplification of peripheral pain signals [2]. Pain pathways associated with cortical, immunological, hormonal, and neuronal changes in chronic pain, are potentially influenced by vitamin D levels [3]. The presence of vitamin D receptor (VDR), 1-hydroxylase, and Vitamin D binding protein (VDBP) in the hypothalamus are suggested as mechanisms by which VDD is implicated in the pathophysiology of FMS [4]. Vitamin D is known to affect several inflamma-

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Conclusion