Abstract
Ovarian germ cell tumors (OGCTs) account for about 15~20% 1 of all ovarian neoplasms . Malignant ovarian germ cell tumors (MOGCTs) are rare, accounting for 3–5% of all 2 malignant ovarian neoplasms . Yolk sac tumor (YST) also referred to as endodermal primitive tumor is the second most 3 common tumor in MOGCTs. YST accounts for 20% of MOGCTs and commonly affects young women and adolescent girls between 18-30 years of age. Around one third 1 of YSTs affect premenarchal girls. When compared with epithelial ovarian tumors, YST is highly malignant with a propensity for rapid growth and acute development of symptoms. YSTs rapidly metastasize, intruding all intra4 abdominal structures as well as retroperitoneal lymph nodes. Before the advent of combination chemotherapy, YSTs were associated with poor prognosis. The introduction of novel chemotherapeutic regimens has been associated with signicantly improved 5-year survival rates of YST from 14% 5 to nearly 90%. The prognosis even for the advanced stages has remarkably improved with the addition of cisplatin to the 6 chemotherapy regimens.
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