Metastatic Squamous Cell Carcinoma of the Neck from Unknown Primary Sites: the Ottawa Regional Cancer Centre (ORCC) Experience

Osama Marglani

doi:10.23937/2378-3419/2/4/1027

Abstract

C l i n M e d International Library Citation: Marglani O, Alherabi AZ, Safar A, Alghamdi S, Eapen L, et al. (2015) Metastatic Squamous Cell Carcinoma of the Neck from Unknown Primary Sites: the Ottawa Regional Cancer Centre (ORCC) Experience. Int J Cancer Clin Res 2:027 Received: September 04, 2015: Accepted: September 23, 2015: Published: September 25, 2015 Copyright: © 2015 Marglani O. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Marglani et al. Int J Cancer Clin Res 2015, 2:3

Highlights

Materials and Methods: We reviewed retrospectively patients with cervical nodal metastases from unknown primary sites, who presented to the Ottawa Regional Cancer Center (ORCC)
In patients who are diagnosed with unknown primary, the combined modality of the treatment that is surgery followed by radiotherapy forms the best mode of management with significantly better survival rates at the end of five years as compare to single modality of treatment
The carcinoma of unknown primary is defined as histological diagnosis of nodal metastasis without detection of primary tumor

Summary

Introduction

The carcinoma of unknown primary is defined as histological diagnosis of nodal metastasis without detection of primary tumor. In 1957 Commes et al [2] described a cervical lymph node metastasis without primary tumor and for the first time defined the disease as carcinoma of unknown primary (CUP) [2]. The management of patient with cervical CUP represents both a diagnostic and therapeutic challenge. A retrospective study of squamous cell carcinoma (SCC) lymph node metastases with unknown primary site was undertaken to evaluate our experience in management and survival. Metastatic squamous cell carcinoma (SCC) to the neck from an unknown primary site presents a challenging diagnostic and therapeutic disease entity, despite a thorough diagnostic workup. We present our experience in management of patients with unknown primary

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Conclusion