Metastatic Pulmonary Calcification Detected on 18F-FDG PET/CT and 99mTc-MDP Bone Scan.

Miju Cheon,Jang Yoo

doi:10.3390/diagnostics11091627

Abstract

Metastatic calcification relates to abnormal calcification resulting from hypercalcemia and can affect soft tissues, skeletal muscle, myocardium, lungs, stomach, kidneys, and blood vessels. We describe a case of metastatic pulmonary calcification in a 71-year-old male, images with 18F-fluorodeoxyglucose (FDG) PET/CT and 99mTc- methylene diphosphonate (MDP) bone scan.

Highlights

30 ng/mL); and parathyroid hormone 15.71 pg/mL (15–65 pg/mL). 18 F-fluorodeoxyglucose (FDG) PET/CT was performed to exclude the possibility of malignancy-related hypercalcemia
The PET/CT images showed an increase in FDG uptake in the bilateral lower lungs (Figure 1)
Since other differential diagnoses were inappropriate for the patient’s clinical condition and a patient with chronic kidney disease accompanied by hypercalcemia, metastatic pulmonary calcification was considered one differential diagnosis

Summary

Metastatic Pulmonary Calcification

Publisher’s Note: MDPI stays neutral with regard to jurisdictional claims in published maps and institutional affiliations. The PET/CT images showed an increase in FDG uptake in the bilateral lower lungs (Figure 1). Correlative non-contrast CT images of the thorax revealed diffuse, hazy ground-glass opacities in the bilateral lower lungs. The patient subsequently underwent a 99m Tc-methylene diphosphonate (MDP) bone scan It revealed significantly increased diffuse uptake in the bilateral lower lung fields (Figure 3). In patients with chronic kidney disease, when hypercalcemia is present and PET/CT shows of 4 ground-glass opacity with mild FDG uptake, metastatic pulmonary calcification can be considered one of the differential diagnoses, though this is rare. Non-contrast CT image of PET/CT (B,E) revealed diffuse, hazy uptake in the remainder of the lungs. The patient subsequently underwent a bone scan It revealed significantly increased diffuse uptake in the bilateral lower lung bone scan.

These findings fields

Author imaging