Abstract
Myxoid/round cell liposarcoma (MRCL), unlike other soft tissue sarcomas, has been associated with unusual pattern of metastasis to extrapulmonary sites. In an attempt to elucidate the clinical features of MRCL with metastatic lesions, 58 cases, from the medical database of Keio University Hospital were used for the evaluation. 47 patients (81%) had no metastases, whereas 11 patients (11%) had metastases during their clinical course. Among the 11 patients with metastatic lesions, 8 patients (73%) had extrapulmonary metastases and 3 patients (27%) had pulmonary metastases. Patients were further divided into three groups; without metastasis, with extrapulmonary metastasis, and with pulmonary metastasis. When the metastatic patterns were stratified according to tumor size, there was statistical significance between the three groups (P = 0.028). The 8 cases with extrapulmonary metastases were all larger than 10 cm. Similarly, histological grading had a significant impact on metastatic patterns (P = 0.027). 3 cases with pulmonary metastatic lesions were all diagnosed as high grade. In conclusion, large size and low histological grade were significantly associated with extrapulmonary metastasis.
Highlights
Liposarcoma is one of the most common subtypes among soft tissue sarcomas constituting 9–18% of all cases [1]
The myxoid/round cell subtype is among the most prevalent and typically occurs in younger individuals [2]. It characteristically occurs in the deep-seated soft tissues of the extremities, especially in the thigh which comprises two-thirds of the group. Another important distinction from other types of liposarcomas is that Myxoid/round cell liposarcoma (MRCL) is associated with an unusual pattern of metastasis to bone such as spine and other soft tissues such as retroperitoneum, limb, and axilla [2, 3]
The predilection of MRCL for extrapulmonary metastases is widely accepted, there is no data regarding which MRCL metastasizes to the lung and which MRCL metastasizes to extrapulmonary sites
Summary
Liposarcoma is one of the most common subtypes among soft tissue sarcomas constituting 9–18% of all cases [1]. The myxoid/round cell subtype is among the most prevalent and typically occurs in younger individuals [2]. It characteristically occurs in the deep-seated soft tissues of the extremities, especially in the thigh which comprises two-thirds of the group. Another important distinction from other types of liposarcomas is that MRCL is associated with an unusual pattern of metastasis to bone such as spine and other soft tissues such as retroperitoneum, limb, and axilla [2, 3]. The purpose of this study is to elucidate the clinical features of MRCL with metastatic lesions
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