Metastatic malignant Brenner tumour in a cervical lymph node – a case report

Abstract

Background: Malignant Brenner tumour (MBT) is a rare ovarian epithelial malignancy that accounts for <0.05% of all ovarian neoplasms. Most cases are limited to the ovary and fallopian tube and lymph node metastasis is uncommon. Aims: We present a case of a 65-year-old woman who was diagnosed with metastatic MBT in a supraclavicular lymph node. Methods: She was initially diagnosed 6 years earlier with ovarian MBT and managed with total abdominal hysterectomy with bilateral salpingo-oophorectomy but declined adjuvant chemotherapy. She was investigated earlier this year for a 1-month history of neck mass. Results: The core biopsy of the neck mass was misdiagnosed as squamous cell carcinoma with focal keratinisation. The slides of the original resection which diagnosed MBT were reviewed in conjunction with the neck mass biopsy and showed similar appearance and immunohistochemical stain profile (p40 and GATA3 positivity). Therefore, the diagnosis was corrected to metastatic MBT following consideration of the overall clinical context and previous pathology. Discussion: This case highlights the importance of clinicopathological correlation and review of relevant previous specimens to ensure accurate diagnoses and optimal clinical management for patients.