Abstract
BackgroundKrukenberg tumors are uncommon and are indicative of an ovarian metastatic carcinoma that originates from another site of primary malignancy. The majority of metastases to ovaries are derived from the stomach and colon. We present a rare case of a metastatic ovarian malignant tumor that originated from gallbladder adenocarcinoma.Case presentationA 45-year-old premenopausal Korean woman presented with abdominal distension. Bilateral multiseptated ovarian tumors and a wall-thickened gallbladder were found on abdominal computed tomography. The patient was diagnosed with metastatic ovarian carcinoma arising from gallbladder adenocarcinoma and was treated with adjuvant chemotherapy.ConclusionsMetastases to the ovaries from other sites, including the gallbladder, are rare and usually resemble primary ovarian tumors. Therefore, potential metastatic ovarian tumors of newly diagnosed pelvic masses should be considered in differential diagnoses.
Highlights
Krukenberg tumors are uncommon and are indicative of an ovarian metastatic carcinoma that originates from another site of primary malignancy
Potential metastatic ovarian tumors of newly diagnosed pelvic masses should be considered in differential diagnoses
We present a rare case of a Krukenberg tumor arising from a gallbladder carcinoma
Summary
The ovary is a common site of metastasis from primary tumors in the stomach, large bowel, appendix, breast, and uterus [1]. The Krukenberg tumor is a classic metastatic lesion to the ovary that is derived from a primary malignancy. A laparotomy was performed based on the preoperative diagnosis of a primary ovarian malignant neoplasm with pathologic finding of gallbladder. Adenocarcinoma was detected in the gallbladder (Fig. 2a). Microscopic examination of both ovarian neoplasms showed bilateral mucinous adenocarcinoma (Fig. 2b), which was a metastasis from the gallbladder. Immunohistochemistry showed that gallbladder adenocarcinoma was focally positive for CDX2 (Fig. 2c). Ovarian adenocarcinoma was positive for CDX2 (Fig. 2d) while negative for an estrogen receptor. There was no clinical and radiologic recurrence noted at the 12-month follow-up after surgery
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