Abstract
Hypercalcemia is a common paraneoplastic syndrome. Transitional cell carcinoma-associated hypercalcemia is rare. Hypercalcemia may develope metastatic calcification. We present a 37-year-old man with transitional cell carcinoma of urinary bladder for many years. In his last admission, a high serum calcium level (5.3-5.6 mmol/L) was noted. Finally, he died of pulmonary edema. An autopsy proved metastatic calcification involved renal tubules, stomach mucosa, and capillary walls of the lungs, salivary ducts and pancreatic ducts. In addition, massive pulmonary edema was also noted. In conclusion, transitional cell carcinoma of urinary bladder may induce hypercalcemia and metastatic calcifications with massive pulmonary edema. So, careful treatment for hypercalcemia in malignancy is important as regards the occurrence of metastatic calcification-associated pulmonary edema.
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