Metastatic brain melanoma in a patient with Noonan syndrome with multiple lentigines

Abstract

Metastatic melanoma of unknown primary origin often presents a major diagnostic and therapeutic challenge to the clinician. Herein, we present a case of metastatic brain melanoma of unknown primary origin in a patient with generalized lentiginosis and features of Leopard syndrome, which is the first case reported to date as of reviewing the literature. This case presents features suggestive of Leopard syndrome. Clinicians must be aware that a malignancy may occur even in the absence of the complete clinical picture of Leopard syndrome.