Abstract
BackgroundAmeloblastoma is a rare benign odontogenic tumor with locally aggressive behavior and a high recurrence rate. When metastases occur, which are uncommon, lungs constitute the most frequent site involved. Malignant ameloblastomas are different from ameloblastic carcinomas. Malignant ameloblastomas are tumors considered metastatic despite the appearance of well-differentiated or benign histology, while ameloblastic carcinomas are histologically malignant in both primary and metastatic sites.Case presentationA 24-year-old Moroccan man presented a malignant ameloblastoma of the mandible. The tumor was entirely resected. Five years later, a local recurrence occurred. Our patient was treated by exclusive radiotherapy with persistence of a residual disease. After two years he developed multiple lung metastases. Our patient received a combination chemotherapy using doxorubicin and cisplatin.ConclusionLess than 50 cases of ameloblastoma with metastases have been reported. There is still no standard treatment for metastatic ameloblastoma. Only through continuous reporting of such cases will clinicians be able to draw an optimal strategy for management of this pathology.
Highlights
Ameloblastoma, from the English word “amel” which means enamel and the Greek word “blastos” which means germ [1], is a rare entity of benign odontogenic tumor. It arises from the epithelium of the dental lamina and it is known by its local aggressive behavior and the high recurrence rate [2]
Malignant ameloblastoma differs from ameloblastoma due to the presence of metastases
We report below a case of an ameloblastoma with metastatic evolution five years after initial surgical treatment
Summary
Ameloblastoma, from the English word “amel” which means enamel and the Greek word “blastos” which means germ [1], is a rare entity of benign odontogenic tumor. It arises from the epithelium of the dental lamina and it is known by its local aggressive behavior and the high recurrence rate [2]. Ameloblastoma is a rare benign odontogenic tumor with locally aggressive behavior and a high recurrence rate. Our patient was treated by exclusive radiotherapy with persistence of a residual disease After two years he developed multiple lung metastases. Our patient received a combination chemotherapy using doxorubicin and cisplatin
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