Abstract
Metaplastic carcinoma of the breast is a rare tumor which accounts for less than 1% of all the primary breast malignancies. It commonly occurs in women more than 50 years of age and are usually triple negative tumors with basal like subtype. Metaplastic carcinomas of breast have a very aggressive behaviour resulting in worse prognosis and a dismal disease free survival. However most metaplastic carcinomas express EGFR, therefore early and correct diagnosis benefits the patient to receive anti-EGFR drugs like cetuximab and geftinib. We are reporting two cases of metaplastic carcinomas, one with spindle cell differentiation and the other with squamous differentiation.
Highlights
Metaplastic carcinoma, accounting for less than 1% of all invasive breast cancers(1), includes a heterogenous group of neoplasms characterized by squamous differentiation or mesenchymal differentiation which includes spindle, osseous, chondroid and rhabdomyoid cells or mixture of both(2)
Case 1: 32 year old woman of reproductive age group presented with complaints of breast lump for 6 months which was initially small with sudden rapid increase in size
Mammogram showed Breast Imaging Reporting and Data System (BI-RADS) 4B lesion measuring 19.5 cm in greatest dimension involving all quadrants of the breast
Summary
Metaplastic carcinoma, accounting for less than 1% of all invasive breast cancers(1), includes a heterogenous group of neoplasms characterized by squamous differentiation or mesenchymal differentiation which includes spindle, osseous, chondroid and rhabdomyoid cells or mixture of both(2). We are reporting two cases of metaplastic carcinoma of the breast, one with spindle cell differentiation and the other with squamous differentiation. Case 1: 32 year old woman of reproductive age group presented with complaints of breast lump for 6 months which was initially small with sudden rapid increase in size. Mammogram showed Breast Imaging Reporting and Data System (BI-RADS) 4B lesion measuring 19.5 cm in greatest dimension involving all quadrants of the breast.
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