Abstract
The use of transition metal complexes as tools for molecular biology is reviewed. Two basic strategies are detailed: the design and synthesis of metal complexes that recognize, bind to, and cleave DNA, and the use of a metal complex [iron(II) EDTA] that cleaves DNA non-specifically through generation of free hydroxyl radical. Application of the latter strategy to the determination of the helical periodicity of viral promoter DNA, and structural details of bent DNA from a trypanosomatid parasite, are presented.
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