Abstract
Handling, transport and storage of biospecimens such as blood and urine without refrigeration are extremely challenging. This formidable challenge leads to an inevitable reliance on a “cold chain” for shipping, handling and storage of biospecimens throughout the world. The cold chain requirement precludes biospecimen procurement from underserved populations and resource-limited settings where refrigeration and electricity are not reliable or even available. Here, we introduce a universal biospecimen preservation approach based on nanoporous material encapsulation for preserving protein biomarkers in biofluids under normal (non-refrigerated) storage conditions. Using urinary NGAL and serum/plasma CA-125 as the model protein biomarkers, we demonstrate that zeolitic imidazolate framework-8 (ZIF-8), a nanoporous material, encapsulation can preserve protein biomarkers in urine, serum, plasma and blood at room temperature and 40°C, with comparable preservation efficacy to the “gold standard” method (freezing li...
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