Metal‐Mediated Reformatsky Reaction of Bromodifluoromethyl Ketone and Imine

Abstract

AbstractThe Reformatsky reaction of bromodifluoromethyl ketones and imines took place readily in the presence of Zn/CuCl at room temperature to afford β‐amino α,α‐difluoro ketones in good yields. Using (S)‐tert‐butanesulfinyl as a chiral auxiliary, the asymmetric Reformatsky reaction was also achieved and found to proceed with excellent diastereoselectivities. A plausible model is proposed to account for the high stereoselectivity of the reaction.