Abstract
Three metallosurfactants C n –Cu–C n (n = 8, 12, 16) were synthesized via two-step in this paper. All of these surfactants were characterized by ultimate analysis, 1H NMR, FT-IR, LC-MS, elemental analysis. In addition, the three surfactants can form vesicles under sonication at a relatively high concentration, and their aggregation behavior and the stability of C n –Cu–C n vesicles were investigated by surface tension, electrical conductivity, FT-IR, negative staining–TEM. Results showed that C12–Cu–C12 vesicles with average size of ∼60 nm had good stability over inorganic salt, temperature, and aging time. Doxorubicin hydrochloride was incorporated into C12–Cu–C12 vesicles with a remarkably high efficiency of above 70 %, and the delivery system has obvious sustained release effect.
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