Abstract
Microbial secondary metabolites continue to inspire chemists and biologists alike with their fascinating structures and potent biological activities. Investigations into their biosynthetic pathways not only provides possible means of creating these molecules in the laboratory but can also reveal new enzymatic reactions and their underlying mechanisms. In this talk, I will present new transformations that my group has discovered in the biosynthesis of complex natural products, with a focus on carbon‐carbon bond formation catalyzed by metalloenzymes. Our efforts are expanding the scope of reactions that microorganisms have at their disposal in concocting bioactive small molecules.Support or Funding InformationThis work was supported by the National Institutes of Health (DP2‐AI‐124786) and the Burroughs Wellcome Fund.This abstract is from the Experimental Biology 2018 Meeting. There is no full text article associated with this abstract published in The FASEB Journal.
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