Metallkomplexe mit biologisch wichtigen Liganden, LXXXIX. Oxidative Addition von elektrophilen α‐Aminosäurederivaten an Platin(II)‐ und Cobalt(I)‐Komplexe: α‐Übergangsmetallierte Aminosäuren

Abstract

Metal Complexes of Biologically Important Ligands, LXXXIXPart LXXXVIII: Ref.[1]. . — Oxidative Addition of Electrophilic Derivatives of α‐Amino Acids to Platinum(II) and Cobalt(I) Complexes: α‐Transition‐Metallated Amino Acids Herrn Professor Dr. Hans Georg von Schnering zum 65. Geburtstag gewidmet. The addition of methyl α‐bromohippurate to PtMe2(bipy) gives the α‐metallated amino acid derivative (bipy)‐Me2(Br)PtC(H)(NHCOPh)(CO2Me) as a mixture of isomers 1a, b of which the trans adduct 1a was characterized by X‐ray diffraction. Methyl α‐bromohippurate and N‐Boc‐O‐tosylserine methyl ester are added to [Co(py)(DH)]− (DH = dimethylglyoxime, diphenylglyoxime) to give cobalt(III) complexes 2–5 with a cobalt‐carbon bond.