Metallkomplexe mit biologisch wichtigen Liganden, LVIII. C‐Allylglycin‐ und C‐Vinylglycin‐Komplexe von Palladium(II), Platin(II), Rhodium(III), Iridium(III) und deren Reaktionen mit Nucleophilen

Abstract

Metal Complexes of Biologically Important Ligands, LVIII. – C‐Allylglycine and C‐Vinylglycine Complexes of Palladium(II), Platinum(II), Rhodium(III), Iridium(III) and Reactions with NucleophilesThe synthesis of the complexes (R13P)(Cl2Pt(C‐allylglycine ester) (1), (2) and of (η5‐C5Me5)Ir(C‐allylglycinate) (6) with tridentate O,N,η2;‐CC allylglycinate as ligand is described. Addition of enolates (Nu−) to the coordinated CC bond of 2 gives the γ‐C‐metallated α‐amino acid ester complexes (3). In most cases the platination occurs stereoselectively to yield the five‐membered metallacycle with the substitutents CH2Nu and CO2R2 in trans position. From 3d the new α‐amino acid H2NCH(CO2Me)‐(CH2)3C(Ph)(CO2Et)21 (4) is cleaved. The structures of 3c and 6 have been determined by X‐ray diffraction. C‐Vinylglycinate can be stabilized at the metal atom in the complexes (10) (MRh, Ir).