Metal–carbon bonds in enzymes and cofactors

Abstract

The sixth volume in the Metal Ions in Life Sciences series, “Metal-Carbon Bonds in Enzymes and Cofactors”, is a comprehensive and authoritative reference covering the current understanding of naturally occurring metal-carbon bonds. The book includes 12 chapters, all authored by experts in their particular area. The volume describes ways that nature uses the organometallic bond to house a latent radical, to stabilize the catalytically active electronic state of a metal ion, and to activate a substrate in an enzymatic reaction. It also describes systems in which the metal-carbon bond represents an inhibited state of an enzyme and ways that chemists use the organometallic bond to probe the active site of an enzyme. The book is recommended for researchers studying any subject relating to transition metal and organometallic chemistry and to the roles of metals in biology.