Abstract
Radiation therapy is one of the most commonly used interventions in cancer therapy. However, innate or acquired radioresistance in several cancers, and toxicity to normal tissues are still serious concerns. In order to enhance radiation response in cancer therapy, metal-based nanoparticles have been widely studied as the radiosensitizers. Recently, more and more studies have demonstrated the potential value of metal-based hybrid nanoparticles (MHNs) as novel radiosensitizers. In this review, we have summarized the applications of MHNs in optimization of radiosensitization, and in combinatorial therapeutic regimes for improving treatment outcomes in cancer therapy.
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