Abstract
The breath gas analysis through gas phase chemical analysis draws attention in terms of non-invasive and real time monitoring. The array-type sensors are one of the diagnostic methods with high sensitivity and selectivity towards the target gases. Herein, we presented a 2 × 4 sensor array with a micro-heater and ceramic chip. The device is designed in a small size for portability, including the internal eight-channel sensor array. In2O3 NRs and WO3 NRs manufactured through the E-beam evaporator’s glancing angle method were used as sensing materials. Pt, Pd, and Au metal catalysts were decorated for each channel to enhance functionality. The sensor array was measured for the exhaled gas biomarkers CH3COCH3, NO2, and H2S to confirm the respiratory diagnostic performance. Through this operation, the theoretical detection limit was calculated as 1.48 ppb for CH3COCH3, 1.9 ppt for NO2, and 2.47 ppb for H2S. This excellent detection performance indicates that our sensor array detected the CH3COCH3, NO2, and H2S as biomarkers, applying to the breath gas analysis. Our results showed the high potential of the gas sensor array as a non-invasive diagnostic tool that enables real-time monitoring.
Highlights
Healthcare is undergoing a paradigm shift that will transform the nature of medicine from reactive to preventive [1]
The sensor array composed of Pt/Ti (80 nm/20 nm thick) interdigitated electrodes (IDEs) was fabricated on a four-inch SiO2/Si wafer through standard photolithography and lift-off processes
Porous nanostructured metal oxides have been mainly used as gas sensing materials because of their large surface-to-volume ratio, narrow necks between each grain, and effective gas accessibility
Summary
Healthcare is undergoing a paradigm shift that will transform the nature of medicine from reactive to preventive [1]. Largescale healthcare methods, which have relied on waiting for the patient to get sick, will be replaced by personalized, predictive, preventive, and participatory (P4) medicine via the convergence of the approaches to disease, useful measurement, visualization techniques, and new computational tools [3]. Based on these needs, monitoring the harmful gases present in the environment or breathing has been extensively concentrated as a suitable healthcare approach [4]. Some chemical vapors, by-products of metabolic processes, show apparent correlation with a particular disease and possibly indicate potential diseases such as asthma [7], diabetes [8], liver diseases [9], lung cancer [10], and metabolic disorders [11], working as biomarkers
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