Abstract
Poisoning and accidental oral intoxication are major health problems worldwide. Considering the insufficient efficacy of the currently available detoxification treatments, a pioneering oral detoxifying adsorbent agent based on a single biocompatible metal-organic framework (MOF) is here proposed for the efficient decontamination of drugs commonly implicated in accidental or voluntary poisoning. Furthermore, the in vivo toxicity and biodistribution of a MOF via oral administration have been investigated for the first time. Orally administered upon a salicylate overdose, this MOF is able to reduce the salicylate gastrointestinal absorption and toxicity more than 40-fold (avoiding histological damage) while exhibiting exceptional gastrointestinal stability (<9% degradation), poor intestinal permeation, and safety.
Highlights
Poisoning and accidental intoxication via ingestion have become growing health issues worldwide with both a significant cost and severe health problems, even death.[1,2]for the vast majority of these poisonings, there are no specific pharmacological antidotes, and currently available detoxification methods are usually ineffective and even involve severe adverse effects, limiting their use.[3−5] In general, activated charcoal is more effective than gastric emptying
Considering the insufficient efficacy of the currently available detoxification treatments, a pioneering oral detoxifying adsorbent agent based on a single biocompatible metal−organic framework (MOF) is here proposed for the efficient decontamination of drugs commonly implicated in accidental or voluntary poisoning
Metal−organic frameworks (MOFs) appear as innovative and promising detoxifying agents. These crystalline hybrid materials, which exhibit exceptional porosity and chemical and structural versatility, have already demonstrated interesting performance in the selective adsorption and removal of hazardous molecules either in water or air.[12−17] certain MOFs have recently emerged in the biomedical field, disclosing interesting features such as important capacities for a large variety of active ingredients and a lack of in vivo toxicity.[18−21] Despite extensive studies for biomedical applications, no biocompatible MOF has been reported to date as an oral drug detoxifying agent
Summary
Poisoning and accidental intoxication via ingestion have become growing health issues worldwide with both a significant cost and severe health problems, even death.[1,2]. Metal−organic frameworks (MOFs) appear as innovative and promising detoxifying agents These crystalline hybrid materials, which exhibit exceptional porosity and chemical and structural versatility, have already demonstrated interesting performance in the selective adsorption and removal of hazardous molecules either in water or air.[12−17] certain MOFs have recently emerged in the biomedical field, disclosing interesting features such as important capacities for a large variety of active ingredients and a lack of in vivo toxicity.[18−21] Despite extensive studies for biomedical applications, no biocompatible MOF has been reported to date as an oral drug detoxifying agent. An ex vivo intestinal model was used to assess MIL-127 and ASA bypass across the intestinal barrier
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