Abstract
New hybrid nanosystems containing the antibacterial substances dioxidine or gentamicin sulfate with bioactive metal (Ag, Cu) nanoparticles have been obtained by a cryogenic freeze-drying method and incorporate further the nanocomposites thus obtained into the cryogenically structured biopolymeric matrices based on gelatin, calcium alginate, and chitosan. FTIR, UV-visible, and NMR spectroscopy, TEM and SEM microscopy data show that the resulting systems consist of wide-porous polymer sponges (pore diameters, 10–200 μm) that contain antibacterial drugs and silver (2–30 nm) or copper (1–5 nm) nanoparticles. The investigation showed that these systems ensure a gradual release of dioxidine (from 40 min up to 3 days), depending on the nature of the matrix and its microstructure. The higher activity of hybrid composites based on nanometals and dioxidine or incorporated into cryostructured biopolymer matrices against the bacterial strains of Escherichia coli 52, Staphylococcus aureus 144 is demonstrated as compared to the individual components in the same matrices.
Highlights
The success of modern pharmacology is associated with production of new drug substances and their pharmaceutical compositions, and with the development of new forms, and especially nanoforms, of already existing drugs
The goal of this work was to synthesize new hybrid nanocomposites based on the antibacterial substance dioxidine and gentamicin sulfate, each combined with the bioactive metal nanoparticles, and to incorporate the obtained nanocomposites into highly porous cryostructured polymer matrices of calcium alginate, gelatin, and chitosan capable for prolonged drug release
A low-temperature synthesis of hybrid composites of dioxidine and gentamicin sulfate with nanoparticles of metals active against antibiotic-resistant microorganisms was carried out
Summary
The success of modern pharmacology is associated with production of new drug substances and their pharmaceutical compositions, and with the development of new forms, and especially nanoforms, of already existing drugs. The use of drug forms with controlled release and prolonged action led to a decrease in the peak concentration of the drug substance in the human body and exclude temporary fluctuations in the concentration of the active substance in the blood and tissues, which are periodically repeated by the use of traditional medical preparations. Such drug forms can be created by.
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