Abstract

Matchmakers have been shown to be valuable for single men and women in both ancient and modern societies. Matchmakers bring together two people who otherwise have little chance of being associated with each other, nurture the closeness between the two parties by enhancing their commonality and smoothing out their differences, and then quietly disappear after the marriage. In this issue, Salgado et al. (1) describe such a matchmaker for single-domain proteins, with significant implications for protein structural evolution and design (Fig. 1).

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