Abstract
Bisindolyl based chromogenic probe with a bispicolyl binding site has been designed, that can form nanoscopic aggregates in water medium. The compound showed selective chromogenic response towards Cu2+ and Hg2+, solution color changes from red to light brown immediately as a result. Interestingly, we can specifically excite either monomer or aggregate species by choosing a suitable excitation channel. The compound showed turn-off response selectively upon addition of Hg2+ when excite at monomer excitation channel (λex = 390 nm). On the contrary, fluorescence quenching was observed with both Cu2+ and Hg2+ ions when excited through the aggregate channel (λex = 470 nm). Not only selectivity, but the sensitivity of the compound towards target metal ions depends on the excitation wavelength. Further, the detection of metal ions, such as Cu2+ and Hg2+ is performed in the biological matrices, such as diluted blood serum and plasma samples, etc. Finally, bioimaging of Hg2+ is achieved both in bacterial (E. Coli) and mammalian (HEK293T) cells.
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