Abstract
the ability of various metal ions to form complexes with proteins leads to the denaturation of the latterand the development of immune response. Such hapten effects cause the well-known phenomenon of nickel-allergiccontact dermatitis. No less typical are side effects of gadolinium compounds, that are used as contrasts for magneticresonance imaging, but cause the development of fibrosis. In both cases an important role belongs to the interactionof metal ions with collagen structures. The aim of our study was to compare in vitro effects of copper and nickel ionson destabilized products of collagen cleavage. Significant difference between these metals in their ability to induce
 aggregation at close to physiological pH values was shown. The influence on the aggregative process of the acidifica-tion of the medium was revealed. It was shown that destabilization of protein structure leads to the formation of highly
 stabilized β-stacked protein aggregates. Comparison of the obtained experimental data with the literature ones makesit possible to approach the understanding of individual mechanisms of toxic effects of metal ions on the human body.
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