Metal-free synthesis of sulfonylated amides through radical aryl migration–desulfonylation

Abstract

A metal-free arylsulfonyl radical-triggered desulfonylation of N-aryl-N-arylsulfonyl-acrylamides under mild conditions for the facile synthesis of a series of sulfonylated amides has been described. The radical transformation simultaneously installs C–S and C–C bonds with concomitant cleavage of N–S and C–S bonds through continuous 5-exo-trig cyclization, desulfonylation, and aryl migration sequence.