Abstract
We report here a novel IBX-promoted oxidative coupling of primary amines and its utilization to Ugi reaction. Advantageously, the reaction could be carried out in choline chloride urea as a natural deep eutectic solvent. A range of imines and bisamides from pseudo-four-component oxidative Ugi reaction could be synthesized under mild and metal-free conditions. Advantageously, the oxidant (IBX) and solvent could be recycled up to five times with only a slight loss in activity.
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