Abstract
AbstractA metal‐free hydrogenation of quinoxalines and indoles with Me3N ⋅ BH3 and TFA in water at room temperature is reported. The protocol is featured with the usage of environmentally friendly water as the solvent, no need of metal catalyst and broad substrate scope. Sensitive functional groups such as OH‐, NH2‐, Cl‐, Br‐, especially ‐CN and ‐CO2Me were well tolerated. Preliminary mechanistic studies suggested that TFA and Me3N ⋅ BH3 provided the proton and hydride sources for the product, respectively.magnified image
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