Abstract
The first chemo- and regioselective one-pot convergent synthesis of 2H-1,3-thiazin-4(3H)-ones has been successfully realized employing β-ketothioamides and alkyne derivatives of N-hydroxyphthalimide (NHPI)-ester under mild conditions in good to excellent yields. The process is triggered by the in-situ generation of dienolate intermediate followed by intramolecular selective N-cyclization. Remarkably, metal- and additive-free conditions, an open atmosphere, non-hazardous reagents, and easy purification are added characteristics to this cascade [3 + 3] annulative strategy. This heteroannulative approach will not only provide an effective method to access various 1,3-thiazin-4-ones but also augment the research domain of thioamides.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
