Abstract
The literature on metal complexes with ethylenediaminedicarboxylic acids and their derivatives as promising pharmacological and diagnostic agents was reviewed. Complexes of platinum-group metals are promising anticancer agents. Bactericidal and fungicidal properties were found for several Pt(IV) and Pd(II) complexes. Complexes of Zn(II) and VO(IV) with ethylenediamine-N,N'-dicarboxylic acids were viewed as hypoglycemic (insulin-mimetic) agents. Complexes of radionuclides (99mTc, 111In, 67Ga) were described as diagnostic radiopharmaceuticals.
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