Metal complexes of anti-inflammatory drugs. Part V. Meclofenamic acid complexes of manganese(II), iron(III), cobalt(II), nickel(II), copper(II) and zinc(II)

Abstract

The preparation, spectroscopic and magnetic properties are reported for complexes of manganese(II), iron(III), cobalt(II), nickel(II), copper(II) and zinc(II) with the anti-inflammatory drug meclofenamic acid. In all the complexes studied the meclofenamic acid acts as a chelate monoanionic ligand with coordination involving the carboxylate oxygen atom and the nitrogen atom of the secondary amine group. The complexes appear to have an octahedral stereochemistry involving two chelate meclofenamate ligands in the case of divalent central metal ions and three chelate meclofenamate ligands in the iron(III) complex. The manganese(II) and copper(II) complexes exhibit marked superoxide dismutase activity in the nitro blue tetrazolium assay.