Abstract

In the present study a series of compounds which consist of two novel Schiff base ligands (L1 and L2) and their cupper, nickel and cobalt complexes (L1-Cu, L1-Ni, L1-Co, L2-Cu, L2-Ni, L2-Co) were synthesized under argon atmosphere. 4-aminomethylpyridine and 4-aminoquinoline were used as primary amines for the syntheses of L1 and L2, respectively, 2,2′-[propane-1,3-diylbis(oxymethylene)]dibenzaldehyde was used as carbonyl compound for both L1 and L2. The structures of synthesized compounds determined by FT-IR, ESI-MS and 1HNMR spectroscopic techniques. TGA-DSC technique was used to determine the thermal decomposition of all synthesized compounds. L1, L1-Ni, L1-Co, L2, L2-Co began to decompose at 250 °C, L1-Cu and L2-Cu at 200 °C, L2-Ni at 300 °C. In vitro Antimicrobial activities of ligands and complexes have been evaluated against three Gram-positive, three Gram-negative bacteria and a fungus using the broth microdilution method. The synthesized compounds possessed the activity against all examined microorganisms having the minimum inhibitory concentration (MIC) values between 9.7 and 5000 μg/mL. L2 and L2-Co showed the best antibacterial activity against S. epidermidis and S. aureus with the low MIC value of 9.7 μg/mL.

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