Abstract
Synthetic chemistry is playing revolutionary role in human beings by synthesizing novel compounds by different techniques. The present study was designed to prepare bioactive compoundsand evaluate their antioxidantand enzyme inhibition studies. Metal complexes of cefixime were prepared by reacting metal salts of different transition metals with sodium salt of cefixime. Their characterization was done with melting point and FTIR studies which confirmed the synthesis of metal complexes. It was concluded from results that synthesized compounds showed very weak response against AChE and some extent to BChE. In contrast to esterase family protease was inhibited significantly and T4 exhibited more than 90% inhibition (93.2 ± 0.1%). Antioxidant study was conducted using well known DPPH free radical assay while enzyme inhibition potential was evaluated according to standard protocols. Maximum antiradical activitywas exhibited by T6 (80.84 ± 1.6%) with IC50 45 ± 2 μg/ml while T5 remained almost inactive. Antibacterial studies have been carried out against Escherichia coli and Bacillus subtilis.
Highlights
Cefixime has broad spectrum of activity, used mostly orally, high stability against β-lactamases and is susceptible to many organisms
Cefixime like other cephalosporins inhibits the synthesis of bacterial cell wall which is the important cellular structure that strengthens the bacterial body and keep them safe from environmental hazards
The aim of this study was to check the biological potential of metal complexes of Cefixime in terms of antibacterial, antioxidant and enzyme inhibition potential
Summary
Cefixime has broad spectrum of activity, used mostly orally, high stability against β-lactamases and is susceptible to many organisms. Cefixime like other cephalosporins inhibits the synthesis of bacterial cell wall which is the important cellular structure that strengthens the bacterial body and keep them safe from environmental hazards. It is efficiently used against number of bacteria including Streptococcus pneumoniae, Staphylococcus aureus, Hemophilus influenzae, Moraxella catarrhalis, Streptococcus pyogenes, Escherichia coli, Klebsiella, Proteus mirabilis, Salmonella, Neisseria gonorrhoeae and Shigella. Unstable free radicals and reactive oxygen species are present in living body from variety of sources. These free radicals may oxidize vital molecules of body like DNA, protein, lipids and nucleic acid leading body to degenerative diseases
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