Abstract
Engineering microbial communities in open environments remains challenging. Here, we describe a platform to identify and modify genetically tractable mammalian microbiota by engineering community-wide horizontal gene transfer events in situ. With this approach, we demonstrate that diverse taxa in the murine gut microbiome can be modified directly with a desired genetic payload. In situ microbiome engineering in living animals enables introduction of novel capabilities into established communities in their native milieu.
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