Abstract
A computer program, MetaCon, has been developed which fully automates all stages of carrying out a control analysis to give values for the flux control, concentration control and branch-point distribution control coefficients of a metabolic pathway. The program input is a text file containing processing instructions and the pathway details. The pathway is analyzed for the presence of branches and moiety-conserved cycles. The results of this stage are used along with inferred and additional elasticity terms to build an elasticity matrix of the form of the Fell and Sauro matrix method1,2, though the process involves symbolic evaluation of Reder’s equations3. Inversion of the matrix yields the expressions for the control coefficients in terms of the elasticities, metabolite concentrations and fluxes which appear in the elasticity matrix. All calculations are carried out algebraically rather than numerically, so that if the values of one or more variables are unknown, the control coefficients will be produced as polynomials in terms of the unknown(s).
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