Abstract
Lung metastasis and metachronous double primary lung cancer are both common and often present diagnostic challenges. We present a case of metachronous isolated contralateral lung metastasis from pulmonary adenosquamous carcinoma with EGFR mutation. A 75-yearold woman presented with left lung nodule on a routine follow-up chest radiograph. She had had surgery for pulmonary adenocarcinoma with EGFR Ex21 L858R mutation 6 years ago. She underwent surgical resection, and histologic findings revealed adenosquamous carcinoma with the same EGFR mutation. Re-assessment of the resected specimen of the primary tumor resected 6 years ago revealed the morphologically similarity to the left lung tumor. Based on morphological and genetic identity, final diagnosis was adenosquamous cell carcinoma and metachronous isolated contralateral lung metastasis. The diagnosis of metachronous isolated metastasis is difficult but important for appropriate management and prediction of prognosis. A careful pathological examination and evaluation of genetic abnormality are needed to make the correct diagnosis.
Highlights
Metachronous isolated contralateral lung metastasis from pulmonary carcinoma is not rare
The epidermal growth factor receptor (EGFR) mutation is one of the most common gene mutations, there has been only one published case report which showed the important role of the EGFR mutation in diagnosis of metachronous isolated contralateral lung metastasis intrapulmonary metastasis or second primary lung adenocarcinoma [1]
We report a prolonged survival case of a metachronous isolated contralateral lung metastasis from pulmonary adenosquamous carcinoma with EGFR mutation, which was evaluated as second primary lung cancer at the time of surgical resection
Summary
Metachronous isolated contralateral lung metastasis from pulmonary carcinoma is not rare. KEYWORDS EGFR mutation; recurrence; lung adenosquamous carcinoma The EGFR mutation is one of the most common gene mutations, there has been only one published case report which showed the important role of the EGFR mutation in diagnosis of metachronous isolated contralateral lung metastasis intrapulmonary metastasis or second primary lung adenocarcinoma [1].
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