Abstract
Malignant involvement of the lung can be primary or metastatic. Although primary lung cancer may be endobronchial, parenchymal or both, metastases to the lung are generally parenchymal. However, less commonly, they may be endobronchial. The lungs are the most common site of metastases among all the malignancies. Common extrapulmonary malignancies causing endobronchial metastases (EBMs) are breast, colorectal and kidney. EBMs from uterine cervical cancer are very rare. Although there are a few case reports in the medical literature describing EBM from cervical cancer, none are from adenocarcinoma histology. In this study, we report a case of EBM which on histopathological examination and immunohistochemistry were found to be from a prior adenocarcinoma cervix. Differentiating EBM from bronchogenic carcinoma and other more common extrapulmonary solid organ malignancies may present a clinico-pathological and radiological challenge.
Highlights
Cancer of the uterine cervix is the third most common cancer in women worldwide.[1,2] in women in developing nations, it is the second most common malignancy and cause of cancer mortality.[3]
We report a case of endobronchial metastases (EBMs) which on histopathological examination and immunohistochemistry were found to be from a prior adenocarcinoma cervix
We are reporting a case of an endobronchial tumour with adenocarcinoma histology in a patient who was treated for cervical cancer 1.5 years prior
Summary
Cancer of the uterine cervix is the third most common cancer in women worldwide.[1,2] in women in developing nations, it is the second most common malignancy and cause of cancer mortality.[3]. We are reporting a case of an endobronchial tumour with adenocarcinoma histology in a patient who was treated for cervical cancer 1.5 years prior. Her background history and IHC helped establish the diagnosis of metastatic cervical adenocarcinoma. We did not find any reported case of cervical cancer with adenocarcinoma histology metastasising endobronchially or the use of p16INK4a IHC marker in an EBM to confirm the uterine cervix as primary site. A 52-year-old woman was referred from a peripheral hospital with dry cough of 2 months duration and rapidly progressive dyspnoea more recently Eighteen months back she was diagnosed as poorly differentiated adenocarcinoma cervix stage III B.
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