Abstract
To evaluate the differences in the metabonomic profile of patients who achieved remisison of Type 2 diabetes mellitus (T2DM) after bariatric surgery in relation to those who presented maintenance or recurrence of this condition after surgery. Thirthy-three patients with obesity and T2D were submitted to bariatric/metabolic surgery, among which, 22 experienced complete remission of T2D, and 11 did not experience remission in the postoperative period. Blood samples were taken in order to assess the serum profiles through a 1H NMR-based metabonomic study. The metabonomic model for the assessment of T2D recurrence presented an accuracy of 93.9%, sensibility of 81.8%, specificity of 100%, positive predictive value of 100% and a negative predictive value of 91.7%. bariatric surgery provide specific effects on the distribution of metabolites in those patients who achieved remission of T2DM, and this new distribution can be assessed through a metabonomic model.
Highlights
Obesity is a disease characterized by chronic and excessive accumulation of adipose tissue due to the long-lasting imbalance between energy intake and expenditure, often resulting in serious damages to the health, such as dysfunctions in metabolic and endocrine activity and nutritional changes[1,2,3,4,5,6]
The sample consisted of 33 individuals, 3 men (12%) and 30 women (88%), with an average age of 51 years, among whom 22 achieved remission of diabetes mellitus tipo 2 (DM2), and 11 presented relapse or maintenance of DM2 after surgery
05 variables were selected to build a model, which resulted in on two discriminant functions presented in the equations below: Figure 1 represents the spectrum obtained through 1H nuclear magnetic resonance spectroscopy (NMR) after the processing described in the Methods
Summary
Obesity is a disease characterized by chronic and excessive accumulation of adipose tissue due to the long-lasting imbalance between energy intake and expenditure, often resulting in serious damages to the health, such as dysfunctions in metabolic and endocrine activity and nutritional changes[1,2,3,4,5,6]. Current metabolic/bariatric surgical techniques result in significant and lasting weight loss, as well as major metabolic improvements[7,8,9,10]. Surgical treatment of obesity appears to be superior to drug treatment regarding glycemic control, given that bariatric surgery can reduce or slow the progression of diabetic nephropathy[11,12]
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
