Abstract
Metabolic pathways are an important part of systems biology research since they illustrate complex interactions between metabolites, enzymes, and regulators. Pathway maps are drawn to elucidate metabolism or to set data in a metabolic context. We present MetaboMAPS, a web-based platform to visualize numerical data on individual metabolic pathway maps. Metabolic maps can be stored, distributed and downloaded in SVG-format. MetaboMAPS was designed for users without computational background and supports pathway sharing without strict conventions. In addition to existing applications that established standards for well-studied pathways, MetaboMAPS offers a niche for individual, customized pathways beyond common knowledge, supporting ongoing research by creating publication-ready visualizations of experimental data.
Highlights
The field of systems biology is based on the integration of data from different biological fields, e.g. transcriptomics, proteomics, metabolomics, modelling, to gain a detailed understanding of an organism
MetaboMAPS assists during interpretation of metabolismassociated data by visualizing experimental data sets on pathway maps
If the pathway map includes unpublished information, it can be uploaded in confidential mode
Summary
The field of systems biology is based on the integration of data from different biological fields, e.g. transcriptomics, proteomics, metabolomics, modelling, to gain a detailed understanding of an organism. Correlating transcriptome or proteome data to metabolome data requires careful revision based on expert knowledge of metabolic pathways and intensive manual work (Cavill et al, 2016). There are pathway maps that can be used for a broad range of different organisms while others are exclusive for a few species. For visualization of multi-omics data, a specific map is required both, regarding the organism and the underlying scientific question. We present MetaboMAPS (Helmecke, 2020), a novel web-based tool that on one hand, serves as a platform to share metabolic pathway maps in an organism-dependent manner. MetaboMAPS assists during interpretation of metabolismassociated data by visualizing experimental data sets on pathway maps
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