Metabolomics in pharmaceutical engineering: Bridging advanced analytics and precision medicine

Abstract

Abstract. The integration of metabolomics into pharmaceutical engineering heralds a new frontier in drug development and precision medicine, offering insights into the intricate dynamics of metabolic responses to pharmaceuticals. This comprehensive review discusses the advancements in analytical technologies, such as mass spectrometry (MS), nuclear magnetic resonance (NMR) spectroscopy, and their hyphenated forms, that have propelled the field of metabolomics. It delves into the utilization of multivariate data analysis, metabolic pathway analysis, and mathematical modeling to interpret complex metabolomic data, facilitating a deeper understanding of drug metabolism, efficacy, and toxicity. Furthermore, the article explores the pivotal role of pharmacometabolomics in personalizing therapy and the regulatory landscape shaping the integration of metabolomics in clinical settings. By highlighting case studies and current methodologies, this review underscores the significant potential of metabolomics in enhancing drug development processes, identifying biomarkers for therapeutic targeting, and advancing the goals of precision medicine.