Abstract
Metabolomics is the latest trend in the “-omics” sciences, of which technologies are widely used today in all life sciences. Metabolomics gave impetus to the description of biochemical processes that occur in many organisms, search for new biomarkers of disease, and laid the foundation for new clinical laboratory diagnostics. The purpose of this review is to show how metabolomics is represented in Russian science, what main research areas were chosen, and to demonstrate the successes and main achievements of Russian scientists in this field. The review is dedicated to the 10th anniversary of Russian metabolomics and also touches on the history of the formation of Russian metabolomics and prospects for the future.
Highlights
Metabolomics is known as a science in which technology platforms are aimed at identifying and quantifying low molecular weight compounds
The area under the ROC curve (AUC) was 0.93 blood plasma metabolites in this study provided a fast, one-step and reproducible approach for analysis
The studies of scientists from Russia on the development of laboratory tests for Parkinson’s disease, impaired glucose tolerance, lung cancer and prostate cancer made a great contribution to this direction [17,18,19,20,21,51,52]
Summary
Metabolomics is known as a science in which technology platforms are aimed at identifying and quantifying low molecular weight compounds (metabolites). Metabolites are substrates and products of almost all biochemical reactions taking place in the body, play a key role in energy generation, signal transmission in the cell, and carry information about the physiological state of a living organism and ongoing pathological processes [1,2,3]. Metabolomics is a relatively new science and the youngest of the triad of basic “-omics”, including genomics and proteomics, which systematically describe biological objects (Figure 1). Along with other “-omics”, metabolomics research focuses on directions where achievements can bring significant benefits to humanity. Metabolomics studies are able to give a representation of the biochemical processes that underlie the body’s reaction to internal and external stimuli
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